Avoid chemotherapy or other toxic tumor-directed systemic treatment for patients with advanced cancer when the likelihood of meaningful life extension or improved quality of life is low. This is especially relevant for patients with reduced (..) Avoid fractionated over single-fraction palliative radiotherapy for uncomplicated painful bone metastases Avoid investigations such as imaging, blood tests, endoscopies, etc., in cancer patients when the likelihood of and impact on treatment or disease management is low Avoid investigations such as imaging, blood tests, endoscopies, etc., to detect early asymptomatic recurrence after curative cancer treatment unless such follow-ups have a proven impact on prognosis or quality of life