Begrunnelse: Nyere forskning viser at kortvarig antibiotikabehandling i mange tilfeller kan være like effektivt som lengre kurer. Dette er vist både for pasienter med alvorlig pneumoni på intensivavdelingen, ved intraabdominal infeksjon der det er kontroll på kilden til infeksjonen og ved gram-negativ bakteremi. Langvarig antibiotikabehandling gir økt risiko for bivirkninger og komplikasjoner som for eksempel Clostridium difficile-kolitt. Behandlingsvarighet med antibiotika må være basert på en forståelse av det naturlige forløpet av den aktuelle infeksjonen, kliniske symptomer og tegn, og inflammasjonsparametere. Dersom det er kildekontroll og god klinisk og biokjemisk respons, bør man vurdere å seponere antibiotika heller enn å fullføre en kur på et angitt antall dager.
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