Begrunnelse:
Dette både av hensyn til miljøet og for å redusere risikoen for utvikling bakterieresistens. Langvarig og unødvendig bruk av klorheksidin kan føre til resistensutvikling og påvirke mikrobiomet negativt. Bruken bør begrenses til situasjoner der det er klart indikert.
Referanser:
- Bescós, R., Bhuminathan, S., Casabene, A., Stanton, M., & Hall, C. (2020). Effects of chlorhexidine mouthwash on the oral microbiome. Scientific Reports. https://doi.org/10.1038/s41598-020-61912-4
- Cieplik, F., Rund, K., Le Cao, K. A., Bewley, K., & He, X. (2023). Chlorhexidine resistance or cross-resistance, that is the question: A mini review. Antibiotics, 12(5), 798. https://doi.org/10.3390/antibiotics12050798
- Kara, G., Blenner, T., & Pan, Y. (2020). Oral biofilms exposure to chlorhexidine results in altered microbial community composition and metabolic function. npj Biofilms and Microbiomes. https://doi.org/10.1038/s41522-020-0124-3
- Saleem, H. G. M., Seers, C. A., Sabri, A. N., Reynolds, E. C., mfl. (2016). Dental plaque bacteria with reduced susceptibility to chlorhexidine are multidrug resistant. BMC Microbiology, 16, 214. https://doi.org/10.1186/s12866-016-0833-1
- Stein, K. W., & Marsh, P. D. (2023). Short-term effects of chlorhexidine mouthwash and essential-oil mouthwash on hospitalized patients’ oral microbiota using 16S rDNA sequencing. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2023.1056534
- Van der Weijden, G. A., Slot, D. E., & Timmerman, M. F. (2020). Current uses of chlorhexidine for management of oral disease: A narrative review. Journal of Dentistry. https://doi.org/10.1016/j.jdent.2020.103456
- Woelber, J. P., Anderson, A., Burkhardt, A.-S., Hellwig, E., Buchalla, W., Hiller, K.-A., Ratka-Krüger, P., Cieplik, F., & Al-Ahmad, A. (2024). Chlorhexidine digluconate mouthwash alters the oral microbial community and increases prevalence of antibiotic resistance genes: A metagenomic analysis. Frontiers in Microbiology.
- Steinberg, D., et al. (2019). Resistance Toward Chlorhexidine in Oral Bacteria — Is There Cause for Concern? Frontiers in Microbiology.